Release 56
(Apr 24, 2025)

QTL 12704 Description:

 Trait Information
Trait name: Antibody response to KLH antigen Vertebrate Trait Ontology: Immune response trait
Reported name: Antibody response to KLH antigen Product Trait Ontology: n/a
Symbol: ABR-KLH Clinical Measurement Ontology: Change in antibody titer
 QTL Map Information
Chromosome:14
QTL Peak Location:50.00 (cM)
QTL Span:n/a
12.3-12.3 (Mbp)
Upper, "Suggestive":n/a
Upper, "Significant":n/a
Peak:rs15012428
Lower, "Significant":n/a
Lower, "Suggestive":n/a
Marker type:SNP
Analysis type:Association
Model tested:Mendelian
Test base:n/a
Threshold significance level:Significant
F_Stat0.005
Dominance effect:n/a
Additive effect:n/a
Associated Gene:AXIN1 (axin 1)
Cis/Trans acting type:
Links:   NCBI GeneDB  |  Edit  |   Map view

 Extended information:
(none)

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  •  QTL Experiment in Brief
    Animals:Birds were from a cross between a native Polish chicken breed (green-legged partridgelike) and White Leghorn.
     Breeds associated:
    n/a
    Design:Birds were genotyped for 7 microsatellite markers on GGA 14 and analyzed for KLH antibody titer. In addition, they were analyzed for 2 SNPs in each of 3 genes, and association with KLH titer was tested.
    Analysis:A half-sib model, a line-cross model, and linkage disequilibrium linkage analysis were used.
    Software:GRID QTL, SAS, Haploview
    Notes: 
    Links:Edit

     Reference
    Authors:Siwek, M; Slawinska, A; Nieuwland, M; Witkowski, A; Zieba, G; Minozzi, G; Knol, E F; Bednarczyk, M;
    Affiliation:Department of Animal Biotechnology, University of Technology and Life Sciences, Mazowiecka 28, 85-225 Bydgoszcz, Poland; siwek@utp.edu.pl
    Title:A quantitative trait locus for a primary antibody response to keyhole limpet hemocyanin on chicken chromosome 14--Confirmation and candidate gene approach.
    Journal:Poultry Sci, 2010, 89(9): 1850-7
    Links:  PubMed  |  Abstract   |  List all data   |  Edit  
    User inputs on reference #20709969
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  • Cite this Data:

    Animal QTLdb: QTL12704 was published in 2010, and was curated into QTLdb on 2012-04-17. DBxREF link to this data: https://www.animalgenome.org/QTLdb/q?id=QTL_ID:12704

     

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