| QTL Map Information |
|---|
| Chromosome: | 8 |
| QTL Peak Location: | 38 (cM) |
| QTL Span: | 35-38 (cM)
10.1-10.9 (Mbp) |
 |
Upper, "Suggestive": | MCW0160 |
| Upper, "Significant": | n/a |
| Peak: | |
| Lower, "Significant": | n/a |
| Lower, "Suggestive": | ADL0345 |
| Marker type: | Microsatellites |
| Analysis type: | QTL |
| Model tested: | n/a |
| Test base: | Genome-wise |
| Threshold significance level: | Suggestive |
 |
P_values | <0.2 | | Dominance effect: | n/a |
| Additive effect: | n/a |
| Associated Gene: | APP (amyloid beta (A4) precursor protein) |
| Cis/Trans acting type: |  |
| Links:
NCBI GeneDB | Edit |
Map view
|
| Extended information: |
|---|
| (none) |
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| QTL Experiment in Brief |
|---|
| Animals: | The first population originated from a cross between 2 divergently selected lines for either high or low primary antibody response to SRBC. The second population was a feather pecking created from a cross between 2 commercial lines of layers. |
| Breeds associated:
n/a
|
| Design: | The Ab level of LPS and LTA in serum from all the birds was determined by ELISA at 5 and 18 wk of age for the H/L population and 38 wk of age for the FP population. Total antibody response was measured 7 d after immunization. |
| Analysis: | For the analysis, only the informative markers for each population were chosen: 170 for H/L population and 180 for FP population. Regression interval mapping was used. Two different genetic models were used: 1) paternal half-sib and 2) line-cross analysis |
| Software: | ASREML software and CriMap |
| Notes: | |
| Links: | Edit |
| Reference |
|---|
| Authors: | Siwek M, Buitenhuis B, Cornelissen S, Nieuwland M, Knol EF, Crooijmans R,Groenen M, Parmentier H, van der Poel J. |
| Affiliation: | Animal Breeding and Genetic Groups, Wageningen University, Wageningen, TheNetherlands. siwek@atr.bydgoszcz.pl |
| Title: | Detection of QTL for innate: non-specific antibody levels binding LPS and LTA intwo independent populations of laying hens. |
| Journal: | Dev Comp Immunol., 2006, 30(7):659-66 |
| Links: |
PubMed | Abstract | List all data
| Edit |
| Additional Information |
|---|
| Comments: | H/L population, half-sib model, 5 weeks |
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