Release 56
(Apr 24, 2025)

QTL 239966 Description:

 Trait Information
Trait name: Facial eczema susceptibility Vertebrate Trait Ontology: n/a
Reported name: (n/a) Product Trait Ontology: n/a
Symbol: FECZ Clinical Measurement Ontology: Disease process measurement
 QTL Map Information
Chromosome:24
QTL Peak Location:n/a
QTL Span:n/a
1.7-1.7 (Mbp)
Upper, "Suggestive":n/a
Upper, "Significant":n/a
Peak:rs425270036
Lower, "Significant":n/a
Lower, "Suggestive":n/a
Marker type:SNP
Analysis type:Association
Model tested:n/a
Test base:Genome-wise
Threshold significance level:Significant
P_values<0.05
Dominance effect:0.08
Additive effect:n/a
Associated Gene:n/a
Cis/Trans acting type:
Links:   Edit  |   Map view

 Extended information:
(none)

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  •  QTL Experiment in Brief
    Animals:Animals were Romney, Coopworth, and Perendale sheep, or a composite of these breeds.
     Breeds associated:
    Design:Animals were genotyped using either the Illumina OvineSNP50 BeadChip (with data imputed to HD) or the Ovine Infinium HD SNP BeadChip, and GWAS was performed for susceptibility to facial eczema, determined by serum concentration of the enzyme gamma-glutamyltransferase 21 days after sporidesmin challenge. A total of 481,400 SNPs were used for analysis.
    Analysis:Two methods were used for GWAS: 1) an Efficient Mixed-Model Association eXpedited (EMMAX) analysis using a kinship matrix was performed on log-transformed serum GGT levels, and 2) genotype association tests were performed on the residuals obtained from ASReml after fitting recorded pedigree and the fixed effect of the contemporary group.
    Software:FImpute, SVS v8.4.0, ASReml
    Notes: 
    Links:Edit

     Reference
    Authors:McRae KM, Rowe SJ, Johnson PL, Baird HJ, Cullen NG, Bixley MJ, Plowman JE, Deb-Choudhury S, Brauning R, Amyes NC, Dodds KG, Newman SN, McEwan JC, Clarke SM
    Affiliation:AgResearch Limited, Invermay Agricultural Centre, Puddle Alley, Mosgiel, Private Bag 50034, New Zealand
    Title:Genomic Tools for the Identification of Loci Associated with Facial Eczema in New Zealand Sheep
    Journal:Genes, 2021, 12(10)
    Links:  PubMed  |  Abstract   |  List all data   |  Edit  
    User inputs on reference #34680955
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  • Cite this Data:

    Animal QTLdb: QTL239966 was published in 2021, and was curated into QTLdb on 2021-12-21. DBxREF link to this data: https://www.animalgenome.org/QTLdb/q?id=QTL_ID:239966

     

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