QTLdb: entrichment tests

Release 56
(Apr 24, 2025)

Whole genome analysis for QTL/association enrichment

Running...

Version: Enrich S: beta v0.8

Search:	to limit the list of your trait choices:
	(optional) focus on chromosome with Mb windows across its length

Data:

Number of immune capacity traits:	27
Number of QTL / associations found:	458
Number of chromosomes where QTL / associations are found:	31

Chi-squared (χ²) test: are immune capacity traits over-represented on some chromosomes?

Chromosomes	Total χ²	df	p-values	FDR ^*	Size of χ²
Chromosome X	174.59091	30	2.490917e-22	6.434869e-22
Chromosome 1	174.59091	30	2.490917e-22	6.434869e-22
Chromosome 2	60.93171	30	0.0007090204	1.156823e-03
Chromosome 3	9.05391	30	0.9999214	9.999996e-01
Chromosome 4	8015.20245	30	9e-41	4.650000e-40
Chromosome 5	5.75262	30	0.9999996	9.999996e-01
Chromosome 6	70.83558	30	3.748896e-05	7.263486e-05
Chromosome 7	26.03205	30	0.6734946	8.351333e-01
Chromosome 8	49.90761	30	0.01267901	1.965247e-02
Chromosome 9	14.06484	30	0.994049	9.999996e-01
Chromosome 10	298.21338	30	5.954309e-46	6.152786e-45
Chromosome 11	41.65425	30	0.07659384	9.893371e-02
Chromosome 12	60.93171	30	0.0007090204	1.156823e-03
Chromosome 13	253.35072	30	3.414017e-37	1.322932e-36
Chromosome 14	140.69349	30	2.913048e-16	6.450321e-16
Chromosome 15	41.65425	30	0.07659384	9.893371e-02
Chromosome 16	253.35072	30	3.414017e-37	1.322932e-36
Chromosome 17	60.93171	30	0.0007090204	1.156823e-03
Chromosome 18	14.06484	30	0.994049	9.999996e-01
Chromosome 19	9.05391	30	0.9999214	9.999996e-01
Chromosome 20	0.09315	30	0.998329325823115	9.999996e-01
Chromosome 21	7076.21535	30	9e-41	4.650000e-40
Chromosome 22	174.59091	30	2.490917e-22	6.434869e-22
Chromosome 23	1669.61277	30	9e-41	4.650000e-40
Chromosome 24	41.65425	30	0.07659384	9.893371e-02
Chromosome 25	41.65425	30	0.07659384	9.893371e-02
Chromosome 26	346.73076	30	1.411787e-55	2.188270e-54
Chromosome 27	140.69349	30	2.913048e-16	6.450321e-16
Chromosome 28	174.59091	30	2.490917e-22	6.434869e-22
Chromosome 29	83.86389	30	5.417823e-07	1.119683e-06
Chromosome 30	346.73076	30	1.411787e-55	2.188270e-54

Chi-squared (χ²) test: Which of the 27 immune capacity traits are over-represented in the QTLdb

Traits	Total χ²	df	p-values	FDR ^*	Size of χ²
Antibody-mediated immune response	85.4133	26	2.996034e-08	2.022323e-07
Basophil number	38.2077	26	0.05792376	8.231271e-02
CD4+CD26+CD45+ cell number	4.65431	26	0.9999989	9.999989e-01
CD8+CD25+CD45+ cell number	9.30862	26	0.9989142	9.999989e-01
CD8+CD26+CD45+ cell number	4.65431	26	0.9999989	9.999989e-01
Cell-mediated immune response	40.56766	26	0.03428480	5.142720e-02
Complement hemolytic activity	36.7111	26	0.0793459	1.071170e-01
ConA-induced cell proliferation	61.89814	26	9.270055e-05	2.275377e-04
Eosinophil number	81.52576	26	1.217449e-07	6.574225e-07
FMDV peptide-induced cell proliferation	74.90795	26	1.247728e-06	4.812665e-06
Gamma-delta T cell number	4.65431	26	0.9999989	9.999989e-01
Granulocyte number	117.67619	26	1.256936e-13	1.696864e-12
Granulocyte percentage	76.27423	26	7.768385e-07	3.495773e-06
Immunoglobulin A level	44.79999	26	0.01237980	2.228364e-02
Immunoglobulin G level	58.12238	26	0.0002982897	6.711518e-04
Immunoglobulin G1 level	30.5539	26	0.245302	3.153883e-01
Immunoglobulin G2 level	229.73307	26	1.597793e-34	4.314041e-33
Immunoglobulin M level	40.94082	26	0.03146214	4.996928e-02
Interleukin-17 level	9.17777	26	0.9990418	9.999989e-01
Interleukin-4 level	18.35553	26	0.8624579	9.999989e-01
Lymphocyte number	51.0774	26	0.002332885	4.845223e-03
Lymphocyte percentage	42.40665	26	0.02228206	3.760098e-02
Monocyte number	45.13518	26	0.01137548	2.193843e-02
Monocyte, eosinophil, and basophil number	87.26421	26	1.524217e-08	1.371795e-07
Neutrophil number	72.9551	26	2.440502e-06	8.236694e-06
Peripheral blood mononuclear cell percentage	65.22515	26	3.202093e-05	9.606279e-05
White blood cell number	64.8825	26	3.577364e-05	9.658883e-05

Correlations found between some of these traits for your reference

No correlation data found on these traits

Overall Test

Data		Chi'Square Test			Fisher's Exact Test
Number of chrom.:	31	χ²	=	19871.292060
Number of traits:	27	df	=	780
Number of QTLs:	458	p-value	=	0

FOOT NOTE: * : FDR is short for "false discovery rate", representing the expected proportion of type I errors. A type I error is where you incorrectly reject the null hypothesis, i.e. you get a false positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where V = Number of Type I errors (false positives); R = Number of rejected hypotheses. Benjamini–Hochberg procedure is a practical way to estimate FDR.