| QTL Map Information |
|---|
| Chromosome: | 22 |
| QTL Peak Location: | 35.7 (cM) |
| QTL Span: | 34.5-36.9 (cM)
21.4-22.9 (Mbp) |
 |
Upper, "Suggestive": | n/a |
| Upper, "Significant": | D9M1722 |
| Peak: | INRA81 |
| Lower, "Significant": | BMS332 |
| Lower, "Suggestive": | n/a |
| Marker type: | Microsatellites |
| Analysis type: | Association |
| Model tested: | Mendelian |
| Test base: | n/a |
| Threshold significance level: | Significant |
 |
P_values | <0.01 | | Dominance effect: | n/a |
| Additive effect: | n/a |
| Associated Gene: | PITX3 (paired-like homeodomain 3) |
| Cis/Trans acting type: |  |
| Links:
NCBI GeneDB | Edit |
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| Extended information: |
|---|
| (none) |
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| QTL Experiment in Brief |
|---|
| Animals: | Animals were Texel sheep. |
| Breeds associated:
|
| Design: | Animals were genotyped for approximately 50,000 SNPs across the genome, then for 3 microsatellite markers in a region of OAR 22, and analyzed for the presence of microphthalmia. |
| Analysis: | Two-point parametric linkage analysis was performed. |
| Software: | PLINK, Merlin |
| Notes: | |
| Links: | Edit |
| Reference |
|---|
| Authors: | Becker D, Tetens J, Brunner A, Bürstel D, Ganter M, Kijas J; International Sheep Genomics Consortium, Drögemüller C |
| Affiliation: | Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland |
| Title: | Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene |
| Journal: | PLoS One, 2010, 5(1): e8689 |
| Links: |
PubMed | Abstract | List all data
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